P6254

Prednison

≥98% (HPLC), powder, anti-inflammatory activity

• Synonym(e): 1,4-Pregnadien-17α,21-diol-3,11,20-trion, 1-Cortison, 17α,21-Dihydroxy-1,4-pregnadien-3,11,20-trion, Dehydrocortison
• Empirische Formel (Hill-System): C₂₁H₂₆O₅
• CAS-Nummer: 53-03-2
• Molekulargewicht: 358.43
• Beilstein: 2065301
• EG-Nummer: 200-160-3
• MDL-Nummer: MFCD00003608
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24898748
• NACRES: NA.77

Eigenschaften

• product name: Prednison, ≥98%
• Biologische Quelle: synthetic
• Sterilität: non-sterile
• Assay: ≥98%
• Form: powder
• mp (Schmelzpunkt): 236-238 °C (lit.)
• Löslichkeit: chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow
• Anwendung(en): hematology
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1
• InChI: 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• Angaben zum Gen: human ... NR3C1(2908)

Beschreibung

Anwendung

Prednisone has been used in dimethyl sulfoxide stock suspension to inject into experimental mice and to analyze the effects of glucocorticoid steroid. It has also been used as a test drug, formulated with peanut butter to study the effects of daily administration of MIDD0301, by animal weight, organ weight and haematological analysis.

Biochem./physiol. Wirkung

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activity. It is useful in treating many disease states and has a half-life of 3.4 to 3.8 hours in plasma. Prednisone is metabolized to prednisolone, which is physiologically active.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H373
• P-Sätze: P260 - P314 - P501
• Gefahreneinstufungen: STOT RE 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges