C2755

Kortison

synthetic, ≥95%, powder

• Synonym(e): 17α,21-Dihydroxy-4-pregnen-3,11,20-trion, 17α-Hydroxy-11-dehydrocorticosteron, 4-Pregnen-17α,21-diol-3,11,20-trion
• Empirische Formel (Hill-System): C₂₁H₂₈O₅
• CAS-Nummer: 53-06-5
• Molekulargewicht: 360.44
• NACRES: NA.77
• PubChem Substance ID: 24278304
• UNSPSC Code: 51111800
• EC Number: 200-162-4
• MDL number: MFCD00003610
• Beilstein/REAXYS Number: 1356062
• Assay: ≥95%
• Form: powder

Eigenschaften

• Produktname: Kortison, ≥95%
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥95%
• form: powder
• technique(s): inhibition assay: suitable
• mp: 223-228 °C (dec.) (lit.)
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
• Gene Information: human ... SERPINA6(866)

Beschreibung

Application

Cortisone has been used:

• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor[1]
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone[2]
• in the determination of rates of cortisol oxidation by 11βHSD[3]

Biochem/physiol Actions

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration.[4] Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)