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P0184

Sigma-Aldrich

Pseudomonas exotoxin A from Pseudomonas aeruginosa

lyophilized powder

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About This Item

CAS-Nummer:
91262-95-2
MDL-Nummer:
MFCD00132134
UNSPSC-Code:
12352200
NACRES:
NA.77

Form

lyophilized powder

Qualitätsniveau

200

Zusammensetzung

Protein, ~30% E1%/280

Lagertemp.

2-8°C

Allgemeine Beschreibung

Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.

Biochem./physiol. Wirkung

Pseudomonas exotoxin A functions as an anticancer agent.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.

Verpackung

Package size based on protein content.

Physikalische Form

Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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USP

USP

1235503

Endotoxin

Anti-Goat IgG (whole molecule)–Peroxidase antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

A5420

Anti-Goat IgG (whole molecule)–Peroxidase antibody produced in rabbit

MOPS ≥99.5% (titration)

Sigma-Aldrich

M1254

MOPS

Ponceau S BioReagent, suitable for electrophoresis

Sigma-Aldrich

P3504

Ponceau S

Mutations in the Elongation Factor 2 Gene Which Confer Resistance to Diphtheria Toxin and Pseudomonas Exotoxin A GENETIC AND BIOCHEMICAL ANALYSES
Foley BT, et al.
The Journal of Biological Chemistry, 270(39), 23218-23225 (1995)
B H Iglewski et al.
Infection and immunity, 15(1), 138-144 (1977-01-01)
Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as
Pseudomonas exotoxin A: from virulence factor to anti-cancer agent
Wolf P and Elsasser-Beile U
International Journal of Medical Microbiology : IJMM, 299(3), 161-176 (2009)
Preparation of Pseudomonas exotoxin A.
K J Kozak et al.
Methods in enzymology, 165, 147-152 (1988-01-01)
J L Middlebrook et al.
Canadian journal of microbiology, 23(2), 183-189 (1977-02-01)
The sensitivities of 21 mammalian cell lines to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae were measured. Each line exhibited 1-4 log differences in sensitivities to the two toxins. No species-specific sensitivities were noted for Pseudomonas exotoxin while diphtheria
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