N2538

NS8593 -hydrochlorid

≥98% (HPLC), powder

• Synonym(e): : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₇N₃ · HCl
• CAS-Nummer: 875755-24-1
• Molekulargewicht: 299.80
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818415
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +54 to +62°, c = 0.5 in methanol
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].C1C[C@@H](Nc2nc3ccccc3[nH]2)c4ccccc4C1
• InChI: 1S/C17H17N3.ClH/c1-2-8-13-12(6-1)7-5-11-14(13)18-17-19-15-9-3-4-10-16(15)20-17;/h1-4,6,8-10,14H,5,7,11H2,(H2,18,19,20);1H/t14-;/m1./s1
• InChIKey: VWEKCDTXUUPBNA-PFEQFJNWSA-N

Beschreibung

Anwendung

NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).

Biochem./physiol. Wirkung

NS8593 hydrochloride inhibits small conductance calcium-activated potassium (SKCa) channels.

The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit ¹²⁵I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca²⁺ to the right, only slightly affecting the maximal Ca²⁺-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca²⁺-dependently (K_d = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• H-Sätze: H413
• Gefahreneinstufungen: Aquatic Chronic 4
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)