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D8946

Sigma-Aldrich

DMH1

≥98% (HPLC), powder, BMP inhibitor

Synonym(e):

4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

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About This Item

Empirische Formel (Hill-System):
C24H20N4O
CAS-Nummer:
1206711-16-1
Molekulargewicht:
380.44
MDL-Nummer:
MFCD18384963
UNSPSC-Code:
51111800
PubChem Substanz-ID:
329798883
NACRES:
NA.77

Produktbezeichnung

DMH1, ≥98% (HPLC)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

light yellow to orange

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

2-8°C

SMILES String

CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChIKey

JMIFGARJSWXZSH-UHFFFAOYSA-N

Allgemeine Beschreibung

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.

Anwendung

DMH1 has been used for bone morphogenetic protein (BMP) inhibition. It has also been used to block vascular endothelial growth factor (VEGF) signaling.

Biochem./physiol. Wirkung

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000381283
0000381283
0000212777
0000271400
0000245337

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Die Dokumentenbibliothek aufrufen

Richard H Row et al.
eLife, 7 (2018-06-08)
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs)
Kwang Bo Jung et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(1), 111-122 (2017-09-01)
Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system is needed for visualizing the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
José M Martín-Durán et al.
Nature, 553(7686), 45-50 (2017-12-14)
It has been hypothesized that a condensed nervous system with a medial ventral nerve cord is an ancestral character of Bilateria. The presence of similar dorsoventral molecular patterns along the nerve cords of vertebrates, flies, and an annelid has been
DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
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