D048

MPP⁺ iodide

≥98% (HPLC), powder

• Synonym(e): 1-Methyl-4-phenylpyridinium iodide
• Empirische Formel (Hill-System): C₁₂H₁₂IN
• CAS-Nummer: 36913-39-0
• Molekulargewicht: 297.13
• MDL-Nummer: MFCD00055096
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24893235
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL, clear
• SMILES String: [I-].C[n+]1ccc(cc1)-c2ccccc2
• InChI: 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
• InChIKey: RFDFRDXIIKROAI-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.[1]induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes.[2] It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells.[3] MPP+ modulates the distribution of dopamine.[4] It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.[5]

Anwendung

MPP+ iodide has been used:

• to induce oxidative stress in zebrafish embryos[6]
• for the inhibition of glutamate uptake in mitochondria of astrocytes[7]
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells[8]

Biochem./physiol. Wirkung

Active metabolite of dopaminergic neurotoxin MPTP

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Vorsicht

Photosensitive.

Angaben zur Herstellung

Solutions should be freshly prepared.

Sonstige Hinweise

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311 + H331,H315,H319,H335
• P-Sätze: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges