A8381

L-Asparagin Monohydrat

≥99% (TLC)

• Synonym(e): (S)-(+)-2-Aminobernsteinsäure-monoamid, (S)-2-Aminobernsteinsäure-4-amid, L-Asparaginsäure-4-amid
• Lineare Formel: NH₂COCH₂CH(NH₂)COOH · H₂O
• CAS-Nummer: 5794-13-8
• Molekulargewicht: 150.13
• Beilstein: 1723527
• EG-Nummer: 200-735-9
• MDL-Nummer: MFCD00151038
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24891338
• NACRES: NA.26

Eigenschaften

• Produktbezeichnung: L-Asparagin Monohydrat, ≥99% (TLC)
• Biologische Quelle: synthetic
• Assay: ≥99% (TLC)
• Form: powder
• Farbe: white to off-white
• mp (Schmelzpunkt): 233-235 °C (lit.)
• Anwendung(en): cell analysis; peptide synthesis
• SMILES String: [H]O[H].N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• InChIKey: RBMGJIZCEWRQES-DKWTVANSSA-N

Beschreibung

Allgemeine Beschreibung

Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues.[1] Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt.[2] It is also present in senescing leaves and germinating seeds.[3]

Anwendung

L-Asparagine monohydrate has been used:

• as a component of Sauton′s and chelated Sauton′s media for mycobacterial growth[4]
• to test its effect in the induction of Ca²⁺ flux in rice roots using aequorin luminescence imaging[5]
• as a component of fermentation medium for the Blakeslea trispora spores[6]

Biochem./physiol. Wirkung

Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport.[2] Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods.[3] Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.[7]

L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)