Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharmaceutical development and technology (2013-11-14)

Srinivasa M Sammeta, Li Wang, Shravan K Mutyam, Kathleen O'Loughlin, Carol E Green, Milton H Werner, Terence Kelly, Gita N Shankar

PMID24218989

RESUMO

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were subjected to in vitro intestinal drug permeability studies conducted with Ussing chambers. Vitamin E tocopherol polyethylene glycol succinate and propylene glycol based co-solvent formulations provided the maximum permeability coefficient for the drug. Inclusion complexes of the drug were prepared using hydroxypropyl-β-cyclodextrin and sulphobutylether cyclodextrins. Pharmacokinetic studies were carried out in male Sprague-Dawley rats for the selected formulations. The relative bioavailabilities of the drug with the co-solvent- and cyclodextrin-based formulations were found to be similar.

MATERIAIS

Número do produto

Marca

Descrição do produto

P3911

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Cloreto de potássio, ACS reagent, 99.0-100.5%

221465

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Hidróxido de sódio, ACS reagent, ≥97.0%, pellets

G7893

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Glicerol, ACS reagent, ≥99.5%

G5516

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Glicerol, for molecular biology, ≥99.0%

S9763

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Fosfato de sódio, ACS reagent, ≥99.0%

S5881

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Hidróxido de sódio, reagent grade, ≥98%, pellets (anhydrous)

G7757

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Glicerol, ReagentPlus^®, ≥99.0% (GC)

415413

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Hidróxido de sódio, 50% in H₂O

B0394

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Ácido bórico, ACS reagent, ≥99.5%

72068

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Hidróxido de sódio, BioUltra, for molecular biology, 10 M in H₂O

71640

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Fosfato de sódio, puriss. p.a., ACS reagent, anhydrous, ≥99.0% (T)

P9541

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Cloreto de potássio, for molecular biology, ≥99.0%

12636

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Cloreto de potássio, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al

S2770

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S8045

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30620

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655104

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06203

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B0252

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W294004

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P4504

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306576

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S8263

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49781

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G9012

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G2025

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04276

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