569251-U

Discovery^® HS C18 (3 µm) HPLC Columns

L × I.D. 7.5 cm × 4.6 mm, HPLC Column

• Sinônimo(s): Discovery RP18 HPLC Column
• Código UNSPSC: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Propriedades

• Nome do produto: Coluna de HPLC C18 Discovery^® HS, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm
• Materiais: stainless steel column
• Agency: suitable for USP L1
• linha de produto: Discovery^®
• Características: endcapped
• fabricante/nome comercial: Discovery^®
• embalagem: 1 ea of
• Extensão da rotulagem: 20% Carbon loading
• Parâmetros: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• técnica(s): HPLC: suitable; LC/MS: suitable
• C × D.I.: 7.5 cm × 4.6 mm
• área da superfície: 300 m²/g
• cobertura de superfície: 3.2 μmol/m²
• Impurezas: <10 ppm metals
• Matriz: silica gel, high purity, spherical particle platform; fully porous particle
• Grupo ativo da matriz: C18 (octadecyl) phase
• tamanho de partícula: 3 μm
• tamanho de poro: 120 Å
• Faixa de pH operacional: 2-8
• aplicação(ões): food and beverages
• técnica de separação: reversed phase

Descrição

Descrição geral

Discovery^® HS C18 HPLC column (L × I.D. 7.5 cm × 4.6 mm) is generally found to be stable under acidic and basic conditions.

Aplicação

• A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research demonstrates the use of the Discovery^® HS C18 HPLC Column in developing a robust HPLC method for analyzing molnupiravir, showcasing its importance in current pandemic-related pharmaceutical research (Recber et al., 2022).


• A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities.: Highlights the adaptability of the Discovery^® HS C18 HPLC Column in environmental monitoring, specifically for pharmaceutical and personal care products, enhancing analytical methods for environmental safety (Portillo-Castillo et al., 2021).


• Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: This study uses the Discovery^® HS C18 HPLC Column to assess terizidone levels in patient plasma, providing critical insights into the treatment of drug-resistant tuberculosis (Mulubwa and Mugabo, 2018).


• Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: Depicts the utility of the Discovery^® HS C18 HPLC Column in optimizing liquid chromatography methods for the potent chemotherapeutic agent doxorubicin, underscoring its role in therapeutic drug monitoring (Maliszewska et al., 2018).


• Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: Showcases the Discovery^® HS C18 HPLC Column′s application in studying the permeability and transport of efavirenz across the placenta, providing valuable pharmacological insights (Zelena et al., 2017).

Características e benefícios

• Estável, com pouco vazamento, para aplicações de LC-MS
• Escalável do analítico ao preparatório
• Altamente estável para garantir excelente reprodutibilidade entre corridas e entre lotes
• Maior hidrofobicidade para melhor resolução de analitos difíceis

   

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Informações legais

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable