569232-U

Discovery^® C18 (5 µm) HPLC Columns

L × I.D. 12.5 cm × 4.6 mm, HPLC Column

• Sinônimo(s): Discovery RP18 HPLC Column
• Código UNSPSC: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Propriedades

• product name: Coluna de HPLC C18 Discovery^®, 5 μm particle size, L × I.D. 12.5 cm × 4.6 mm
• Materiais: stainless steel column
• Agency: suitable for USP L1
• linha de produto: Discovery^®
• Características: endcapped
• fabricante/nome comercial: Discovery^®
• embalagem: 1 ea of
• Extensão da rotulagem: 12% Carbon loading
• Parâmetros: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• técnica(s): HPLC: suitable; LC/MS: suitable
• C × D.I.: 12.5 cm × 4.6 mm
• área da superfície: 300 m²/g
• cobertura de superfície: 3 μmol/m²
• Impurezas: <10 ppm metals
• matriz: silica gel, high purity, spherical particle platform; fully porous particle
• Grupo ativo da matriz: C18 (octadecyl) phase
• tamanho de partícula: 5 μm
• tamanho de poro: 180 Å
• operating pH range: 2-8
• aplicação(ões): food and beverages
• técnica de separação: reversed phase

Descrição

Descrição geral

Use a coluna C18 Discovery® para qualquer método que especifique C18. A forma de pico, reprodutibilidade e estabilidade excepcionais significam que essa é a coluna ideal para todos os métodos de C18, desde os mais complicados até os de rotina.

Aplicação

• Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson′s Disease Candidate, Using LC-MS/MS and LC-HRMS.: This study underscores the utility of theDiscovery^® C18 HPLC Column in pharmacokinetic profiling and metabolite identification of a novel therapeutic agent, demonstrating its critical role in the development of Parkinson′s disease treatments (Choi et al., 2024).


• Determination of 2,4-dimethylhydroxybenzene by chromatographic methods in forensic toxicological research of biological material.: Highlights the application of the Discovery^® C18 HPLC Column in forensic toxicology, enhancing the detection and quantification of toxic substances within biological samples, vital for legal and medical investigations (Chernova et al., 2024).


• High-throughput microfluidic chip with silica gel-C18 channels for cyclotide separation.: Illustrates the integration of the Discovery^® C18 HPLC Column in a microfluidic setting for efficient and high-throughput separation of cyclotides, offering advancements in peptide and protein analysis (Ebrahimi et al., 2023).


• Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention.: This research utilizes the Discovery^® C18 HPLC Column for the advanced study of microbial metabolism under nanoparticle intervention, pushing the boundaries of biotechnological and pharmaceutical research (Al-Theyab et al., 2023).


• A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction.: Demonstrates the versatility of the Discovery^® C18 HPLC Column in complex botanical analyses, particularly in enhancing the reliability of ginsenoside identification, crucial for the development of herbal medicinal products (Sun et al., 2023).

Características e benefícios

• Excelente reprodutibilidade
• Forma de pico excepcional para analitos básicos e ácidos
• Separações por LC-MS estáveis, com pouco vazamento
• Separação de peptídeos e proteínas pequenas
• Menor hidrofobicidade que muitas colunas C18 comparáveis, o que propicia uma análise mais rápida

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Informações legais

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany