R1656
RAF1 (EE) (306-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
CMD1NN, NS5, RAF proto-oncogene serine/threonine-protein kinase, cRaf
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10 μG
R$ 4.188,00
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10 μG
R$ 4.188,00
About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
fonte biológica
fermentation/recombinant
Nível de qualidade
recombinante
expressed in baculovirus infected Sf9 cells
linha de produto
PRECISIO® Kinase
Ensaio
≥70% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
atividade específica
5100-6900 nmol/min·mg
peso molecular
~63 kDa
fabricante/nome comercial
Precision
técnica(s)
cell based assay: suitable
solubilidade
water: soluble
nº de adesão de ID de proteína
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... RAF1(5894)
Descrição geral
Research area: Cell Signaling
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Ações bioquímicas/fisiológicas
Rapidly Accelerated Fibrosarcoma 1(RAF1), a member of MAP kinase kinase kinase (MAP3K) family plays a vital role in cell signaling by directly interacting with GTPases and functions downstream in their signaling pathway.[4] RaF1 is activated by Ras in the presence of growth-promoting signals, leading to the activation of mitogen-activated protein kinase kinase (MEK1/MEK2) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2) downstream. [5] The activated ERK proteins control gene expression related to cell division, apoptosis, cell differentiation, and cell migration.[4] The gene is mutated or upregulated in prostate and bladder cancer.[5] Also, mutations are associated with Noonan syndrome, which leads to various physical abnormalities like craniofacial dysmorphisms, ocular, and musculoskeletal irregularities, neurocognitive impairment, and cardiac malformations.[4]
forma física
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Informações legais
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Wong S, et al.
EMBO Molecular Medicine, 15(5), e17078-e17078 (2023)
Benjamin R Nixon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1138-1150 (2018-08-15)
Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have identified a novel splice isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf1-tr). We found
Vertical pathway targeting in cancer therapy
Shahbazian D, et al.
Advances in Pharmacology, 65, 1-26 (2012)
Olafur Andri Stefansson et al.
Breast cancer research : BCR, 13(3), 309-309 (2011-06-16)
Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a
U R Rapp et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(14), 4218-4222 (1983-07-01)
We have molecularly cloned a unique acutely transforming replication-defective mouse type C virus (3611-MSV) and characterized its acquired oncogene. The viral genome closely resembles Moloney (M) murine leukemia virus (MuLV), except for a substitution in M-MuLV in the middle of
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