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P4904

Sigma-Aldrich

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

≥98%

Sinônimo(s):

1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate, 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl, PAF(C16), Platelet activating factor

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1 MG
R$ 565,00
5 MG
R$ 1.389,00
10 MG
R$ 3.017,00
25 MG
R$ 6.297,00

R$ 565,00

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1 MG
R$ 565,00
5 MG
R$ 1.389,00
10 MG
R$ 3.017,00
25 MG
R$ 6.297,00

About This Item

Fórmula empírica (Notação de Hill):
C26H54NO7P · xH2O
Número CAS:
74389-68-7
Peso molecular:
523.68 (anhydrous basis)
Beilstein:
3574588
Número MDL:
MFCD00150679
Código UNSPSC:
12352211
ID de substância PubChem:
24898570
NACRES:
NA.77

R$ 565,00

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Ensaio

≥98%

Formulário

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O

InChI

1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1

chave InChI

HFMSDOHEENWULV-UFTMZEDQSA-N

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Aplicação

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:
  • to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils[1]
  • to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro[2]
  • to determine its effects on cervical ripening and leukocyte infiltration in rat models[3]

Ações bioquímicas/fisiológicas

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid[4], and a pro-inflammatory lipid mediator.[5] It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability.[5] PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.[6]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCN0535
BCCG8643
BCCG4701
BCCB6898
BCBW2009

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Damien Garrido et al.
Frontiers in veterinary science, 4, 226-226 (2018-01-13)
Lipid mediators are known to play important roles in the onset and resolution phases of the inflammatory response in mammals. The phospholipid platelet-activating factor (PAF) is a pro-inflammatory lipid mediator which participates in vascular- and innate immunity-associated processes by increasing
Luis Alexandre Muehlmann et al.
Research in veterinary science, 93(1), 393-397 (2011-08-09)
Phagocytosis exerted by alveolar macrophages and neutrophils is crucial in the clearance of exogenous particles deposited in the airways. Therefore, substances that activate these phagocytes in the airways can exert important effects on the particle clearance rate. PAF, particularly, was
Holger Maul et al.
American journal of obstetrics and gynecology, 187(4), 829-833 (2002-10-22)
The purpose of this study was to determine the effect of locally applied platelet-activating factor on cervical ripening and leukocyte infiltration. Timed-pregnant rats were treated vaginally twice each day on days 14 and 15 of gestation with platelet-activating factor 5
Platelet-activating factor.
S M Prescott et al.
The Journal of biological chemistry, 265(29), 17381-17384 (1990-10-15)
S Grassi et al.
Neuroscience, 94(2), 549-559 (1999-12-01)
In rat brainstem slices, we investigated the interaction between platelet-activating factor and group I metabotropic glutamate receptors in mediating long-term potentiation within the medial vestibular nuclei. We analysed the N1 field potential wave evoked in the ventral portion of the
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