P3782

L-αfosfatidilcolina

solution, from soybean, suitable for cell culture, Type III-S

• Sinônimo(s): 1,2-Diacil-sn-glicero-3-fosfocolina, 3-sn-fosfatidilcolina, L-αlecitina, Azolectina, PC
• Número CAS: 8002-43-5
• Beilstein: 5209585
• Código UNSPSC: 12352211
• NACRES: NA.75

Propriedades

• fonte biológica: soybean
• tipo: Type III-S (III is the third type of Phosphatidylcholines produced; S is for Soybean.)
• Ensaio: ≥98%
• forma: solution
• concentração: 100 mg/mL in chloroform
• técnica(s): cell culture | mammalian: suitable
• temperatura de armazenamento: −20°C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• chave InChI: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Descrição

Descrição geral

Phosphatidylcholine is a phospholipid comprising a choline head group and is associated with organelle membrane and cytomembrane.

Aplicação

L-α-Phosphatidylcholine has been used in phospholipid solid phase enzyme-linked immunosorbent assay (ELISA) to test its interaction with Factor VIII variants (N0 and N6). It has also been used in the synthesis of phosphatidylcholine hydroperoxide (PCOOH) substrate for the glutathione peroxidase (GPx4) assay.

Ações bioquímicas/fisiológicas

Phosphatidylcholine is essential for acetylcholine synthesis and is crucial for very-low-density lipoprotein secretion in hepatocytes. The pathophysiology of non-alcoholic fatty liver disease (NAFLD) displays a variation in the hepatic PC to phosphatidylethanolamine (PE) ratio. PC alleviates inflammation in ulcerative colitis (UC) and its administration is effective for treating benign symmetric lipomatosis.

Fosfolipídio estrutural importante no cérebro, contendo cerca de 15% de lipídios no total, localizado principalmente na massa cinzenta.

Nota de preparo

Prepared Chromatographically.
Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H302,H315,H319,H331,H336,H351,H361d,H372
• Declarações de precaução: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Órgãos-alvo: Central nervous system, Liver,Kidney
• Código de classe de armazenamento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter