P7443

L-αfosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

• Sinônimo(s): 1,2-Diacil-sn-glicero-3-fosfocolina, 3-sn-fosfatidilcolina, L-αlecitina, Azolectina, PC
• Número CAS: 8002-43-5
• Beilstein: 5209585
• Número CE: 232-307-2
• Código UNSPSC: 12352211
• NACRES: NA.25

Propriedades

• fonte biológica: soybean
• Nível de qualidade: 200
• Ensaio: ≥99% (TLC)
• Formulário: lyophilized powder
• grupo funcional: phospholipid
• tipo de lipídio: phosphoglycerides
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• chave InChI: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Descrição

Descrição geral

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk.[1] It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes.[2] It is essential for the acetylcholine synthesis functions to nourish the brain.[1] PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD).[3] It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease.[4] PC administration therapy is effective for treating benign symmetric lipomatosis.[5]

Aplicação

L-α-Phosphatidylcholine has been used:

• for liposome preparation[6]
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)[7]
• as a component of serum free substitute for whole blood cells[8]

Ações bioquímicas/fisiológicas

Fosfolipídio estrutural importante no cérebro, contendo cerca de 15% de lipídios no total, localizado principalmente na massa cinzenta.

Embalagem

Packaged under Argon

Nota de preparo

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)