O1637
Oncostatin M from mouse
BioReagent, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinônimo(s):
OSM
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25 μG
R$ 5.037,00
R$ 5.037,00
Previsão de entrega em17 de abril de 2025
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25 μG
R$ 5.037,00
About This Item
R$ 5.037,00
Previsão de entrega em17 de abril de 2025
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
recombinante
expressed in E. coli
linha de produto
BioReagent
Ensaio
≥97% (SDS-PAGE)
Formulário
lyophilized powder
potência
0.25-1 ng/mL EC50
peso molecular
21 kDa
embalagem
pkg of 25 μg
técnica(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
mouse ... Osm(18413)
Aplicação
Oncostatin M from mouse has been used in the preparation of culture medium for primary culture of mouse fetal hepatoblasts (MFHs).
Ações bioquímicas/fisiológicas
Oncostatin M, LIF, G-CSF, IL-6, and ciliary neurotrophic factor (CNTF) are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. Oncostatin M is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. Oncostatin M is secreted by macrophages and activated T lymphocytes.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.
Nota de análise
The biological activity of recombinant mouse OSM was measured by its ability to stimulate 3H-thymidine incorporation in quiescent NIH/3T3 cells.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Tadasuke Komori et al.
Diabetologia, 58(8), 1868-1876 (2015-05-15)
Obesity and insulin resistance are closely associated with adipose tissue dysfunction caused by the abnormal recruitment of inflammatory cells, including macrophages. Oncostatin M (OSM), a member of the IL-6 family of cytokines, plays important roles in a variety of biological
Huang-Ju Tu et al.
Journal of cellular physiology, 228(5), 983-990 (2012-10-09)
Oncostatin M (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads
Sema Becerik et al.
Journal of periodontology, 83(10), 1304-1313 (2012-01-18)
The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases. Eighty individuals
Nikolay Ishkitiev et al.
Journal of endodontics, 38(4), 475-480 (2012-03-15)
We have previously differentiated hepatocyte like cells from deciduous tooth pulp stem and extracted third molar pulp stem cells with a protocol that used fetal bovine serum, but it showed high contaminations of nondifferentiated cells. Both the lower purity of
Marten Szibor et al.
Cellular and molecular life sciences : CMLS, 71(10), 1907-1916 (2013-12-11)
Cardiomyocytes continuously generate the contractile force to circulate blood through the body. Imbalances in contractile performance or energy supply cause adaptive responses of the heart resulting in adverse rearrangement of regular structures, which in turn might lead to heart failure.
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