O1383

Oleic acid

BioReagent, suitable for cell culture

• Sinônimo(s): cis-9-Octadecenoic acid, Elainic acid
• Fórmula linear: CH₃(CH₂)₇CH=CH(CH₂)₇COOH
• Número CAS: 112-80-1
• Peso molecular: 282.46
• Beilstein: 1726542
• Número CE: 204-007-1
• Número MDL: MFCD00064242
• Código UNSPSC: 12352211
• ID de substância PubChem: 24897941
• NACRES: NA.75

Propriedades

• fonte biológica: palm oil
• pressão de vapor: 1 mmHg ( 176 °C)
• linha de produto: BioReagent
• Ensaio: ≥99% (GC)
• forma: viscous liquid
• técnica(s): cell culture | mammalian: suitable
• índice de refração: n20/D 1.459 (lit.)
• pb: 194-195 °C/1.2 mmHg (lit.)
• pf: 13-14 °C (lit.)
• solubilidade: ethanol: soluble
• densidade: 0.89 g/mL at 25 °C (lit.); 0.89 g/mL at 25 °C (lit.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCCCCC\C=C/CCCCCCCC(O)=O
• InChI: 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
• chave InChI: ZQPPMHVWECSIRJ-KTKRTIGZSA-N
• Informações sobre genes: human ... SOAT1(6646) , SOAT2(8435)

Descrição

Descrição geral

Oleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand.

Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state. Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.

Aplicação

Oleic acid has been used:

• in fatty acid oxidation rate experiments in myotubes and in Sirt1 enzyme assay
• to determine quantitatively its effect on lipid droplets by optical diffraction tomography
• as a fatty acid source in the medium for primary hepatocyte culture

Embalagem

Sealed ampule.

Atenção

Unsaturated fatty acids are subject to oxidation and peroxidation. Consider complexed fatty acid supplements.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Equipamento de proteção individual: Eyeshields, Gloves, type ABEK (EN14387) respirator filter