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O1257

Sigma-Aldrich

Oleic Acid-Water Soluble

powder, BioReagent, suitable for cell culture

Sinônimo(s):

Oleic Acid–Cyclodextrin Complex

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10 MG
R$ 706,00

R$ 706,00


Previsão de entrega em02 de abril de 2025


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10 MG
R$ 706,00

About This Item

Número MDL:
Código UNSPSC:
12352211
ID de substância PubChem:
NACRES:
NA.75

R$ 706,00


Previsão de entrega em02 de abril de 2025


Solicite uma grande encomenda

fonte biológica

synthetic (organic)

Nível de qualidade

linha de produto

BioReagent

Formulário

powder

composição

Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)

técnica(s)

cell culture | mammalian: suitable

solubilidade

H2O: 50 mg/mL, clear to slightly hazy

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCCCCCCC\C=C/CCCCCCCC(O)=O

InChI

1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-

chave InChI

ZQPPMHVWECSIRJ-KTKRTIGZSA-N

Informações sobre genes

Aplicação

Oleic Acid-Water Soluble has been used:
  • to prepare the FFAs (free fatty acids) mixture for cell treatment[1]
  • to investigate its effect on the solute carrier family 2 member 4 (SLC2A4)/GLUT4 expression in L6 muscle cells and as potential transcriptional regulators[2]
  • in the preparation of fatting media for the induction of in vitro steatosis in primary human hepatocytes[3]

Outras notas

Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media.

produto relacionado

Nº do produto
Descrição
Preços

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
Poletto A C, et al.
Molecular and Cellular Endocrinology, 401(12), 65-72 (2015)
A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis
Ai L, et al.
International Journal of Biological Sciences, 11(12), 1436-1436 (2015)
Shuo Li et al.
International journal of biological sciences, 17(15), 4165-4175 (2021-11-23)
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor of cytokine signaling 2 (SOCS2) is one of classic negative regulators of cytokine signaling, which has recently been described as anti-inflammatory mediators. However, the
Pu Sun et al.
Journal for immunotherapy of cancer, 9(8) (2021-08-11)
The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
Kangpeng Jin et al.
Theranostics, 10(12), 5290-5304 (2020-05-07)
Rationale: Inflammation plays a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Protein tyrosine phosphatase receptor type O truncated isoform (PTPROt) is an integral membrane protein that has been identified in osteoclasts, macrophages, and B lymphocytes. However, its relationship

Artigos

Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.

How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

Questions

  1. Could you please clarify whether the entire 10mg of the compound is oleic acid, or does the 10mg compound actually contain 377ug (37.7mg/g * 10mg) of oleic acid, considering the specified concentration?

    1 answer
    1. This product is a mixture of Oleic acid and Cyclodextrin. Each gram of powder will include a minimum of 28 mg Oleic acid. The product is sold by Oleic acid content. At the minimum Oleic acid content, the 10 mg package size would contain a total of 357 mg of powder. The Oleic acid content is lot specific. Please see the link below to review a sample or lot specific Certificate of Analysis:
      https://www.sigmaaldrich.com/product/sigma/o1257#product-documentation

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