Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

N3290

Sigma-Aldrich

NKH 477

≥98% (HPLC), powder, adenylyl cyclase activator

Sinônimo(s):

6-[3-(dimethylamino)propionyl]-forskolin, Colforsin dapropate hydrochloride, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

5 MG
R$ 825,00
25 MG
R$ 3.322,00

R$ 825,00

Previsão de entrega em30 de maio de 2025

Solicite uma grande encomenda
Todas as fotos(1)

Selecione um tamanho

Alterar visualização
5 MG
R$ 825,00
25 MG
R$ 3.322,00

About This Item

Fórmula empírica (Notação de Hill):
C27H43NO8·HCl
Número CAS:
138605-00-2
Peso molecular:
546.09
Número MDL:
MFCD00236421
Código UNSPSC:
12352200
ID de substância PubChem:
329818606
NACRES:
NA.77

R$ 825,00

Previsão de entrega em30 de maio de 2025

Solicite uma grande encomenda

Nome do produto

NKH 477, ≥98% (HPLC), powder

Ensaio

≥98% (HPLC)

Formulário

powder

condição de armazenamento

desiccated

cor

white to beige

solubilidade

H2O: 3 mg/mL, clear to slightly hazy (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C

InChI

1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

chave InChI

VIRRLEDAYYYTOD-YHEOSNBFSA-N

Categorias relacionadas

Ações bioquímicas/fisiológicas

NKH 477 is a potent, orally active adenylyl cyclase activator.
NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Nota de preparo

A clear to slightly hazy solution is possible.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000396626
0000396659
0000392627
0000396659
0000396626

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 2

1 of 2

3-Isobutil-1-metilxantina ≥99% (HPLC), powder

Sigma-Aldrich

I5879

3-Isobutil-1-metilxantina

Rhodamine B for fluorescence

Sigma-Aldrich

83689

Rhodamine B

Li-Hua Hang et al.
Pharmacological reports : PR, 65(3), 710-716 (2013-08-21)
It has been shown that spinal PKA/CREB signaling pathway is involved in neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously been investigated. The aim of this study was to examine the potential role of
Saw Marlar et al.
American journal of physiology. Cell physiology, 306(6), C598-C606 (2014-01-24)
Regulated urine concentration takes place in the renal collecting duct upon arginine vasopressin (AVP) stimulation, where subapical vesicles containing aquaporin-2 (AQP2) are inserted into the apical membrane instantly increasing water reabsorption and urine concentration. The reabsorped water exits via basolateral
Chin-San Loo et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17119-17124 (2013-10-03)
In kidney collecting duct cells, filamentous actin (F-actin) depolymerization is a critical step in vasopressin-induced trafficking of aquaporin-2 to the apical plasma membrane. However, the molecular components of this response are largely unknown. Using stable isotope-based quantitative protein mass spectrometry
Mika Shirasu et al.
Neuron, 81(1), 165-178 (2013-12-24)
Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various
Mika Takarada-Iemata et al.
Journal of neurochemistry, 130(3), 374-387 (2014-04-05)
N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation- and stress-associated molecule predominantly expressed in astrocytes in the CNS. In this study, we examined the expression and the role of Ndrg2 after cortical stab injury. We observed that Ndrg2 expression was
Exibir todos os documentos relacionados

Artigos

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica