M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
Sinônimo(s):
MEG hemisulfate salt
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About This Item
Fórmula linear:
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
Número CAS:
Peso molecular:
168.23
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Ensaio
≥98%
Formulário
solid
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
chave InChI
XJKZAAUVINNNNC-UHFFFAOYSA-N
Aplicação
Selective iNOS inhibitor and scavenger of peroxynitrite.
Ações bioquímicas/fisiológicas
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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J E Irazuzta et al.
Life sciences, 67(4), 365-372 (2000-09-26)
Reactive oxygen and nitrogen species participate in the inflammatory process during meningitis. Among them, superoxide, nitric oxide (NO), and their reaction product peroxynitrite exert cytotoxic effects. Mercaptoethylguanidine (MEG) exerts beneficial effects in in vivo inflammatory conditions by scavenging peroxynitrite and
Christian Kellner et al.
Cancer letters, 215(1), 43-52 (2004-09-18)
We investigated the early events involved in loss of mitochondrial membrane potential (DeltaPsi(mt)) leading to apoptosis in cells derived from patients with acute lymphocytic leukemia after exposure to phenolic antioxidants. Using the nitric oxide binding dye diaminofluorescein-FM diacetate, we found
M Kiroycheva et al.
Journal of the American Society of Nephrology : JASN, 11(6), 1026-1032 (2000-05-23)
Previous studies in beta(s) sickle cell mice demonstrated renal immunostaining for nitrotyrosine, which is putative evidence of peroxynitrite (ONOO(-)) formation. ONOO(-) is known to nitrate tyrosine residues of various enzymes, thereby interfering with phosphorylation and inactivating them. The present study
B Zingarelli et al.
The Journal of pharmacology and experimental therapeutics, 287(3), 1048-1055 (1998-12-24)
The effect of mercaptoethylguanidine (MEG), a selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger, was evaluated in a rat model of colonic injury. A single intracolonic administration of trinitrobenzene sulfonic acid (TNBS, 20 mg/kg) dissolved in ethanol
Mustafa Ozturk et al.
Journal of pineal research, 50(1), 89-96 (2010-11-11)
Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG)
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