M3824

α-Mangostin

≥98% (HPLC)

• Sinônimo(s): α-MG, alpha-Mangostin
• Fórmula empírica (Notação de Hill): C₂₄H₂₆O₆
• Número CAS: 6147-11-1
• Peso molecular: 410.46
• Número CE: 448-420-7
• Número MDL: MFCD00135200
• Código UNSPSC: 12352212
• ID de substância PubChem: 329817982
• NACRES: NA.25

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• solubilidade: methanol: 1 mg/mL, clear, very light yellow
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1c(O)cc2Oc3cc(O)c(C\C=C(\C)C)c(O)c3C(=O)c2c1C\C=C(/C)C
• InChI: 1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
• chave InChI: GNRIZKKCNOBBMO-UHFFFAOYSA-N

Descrição

Descrição geral

α-Mangostin (α-MG) is the most abundant phytochemical derived from the pericarp of Garcinia mangostana L..[1] It is a tetraoxygenated diprenylated xanthone.[2] The chemical structure of α-MG molecule is 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one.[2]

Aplicação

α-Mangostin has been used:

• to study its protective effect against oxidative stress mediated-retinal cell death[3]
• to study its role as an antigenotoxic agent in DNA protection against oxidative damage[4]
• to understand its anti-bacterial activity against Staphylococcus epidermidis RP62A[5]

Ações bioquímicas/fisiológicas

α-Mangostin displays various pharmacological properties both in in vitro and in vivo studies.[6] These include antimicrobial, anticarcinogenic, antidiabetic, neuroprotective, hepatoprotective[1] and anti-inflammatory properties.[7]

Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory.

Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable