A7687

Aloe-emodin

≥95% (HPLC)

• Sinônimo(s): 1,8-Dihydroxy 3-hydroxymethylanthraquinone, 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₅
• Número CAS: 481-72-1
• Peso molecular: 270.24
• Beilstein: 2059062
• Número CE: 207-571-7
• Número MDL: MFCD00017373
• Código UNSPSC: 12352205
• ID de substância PubChem: 24891267
• NACRES: NA.79

Propriedades

• fonte biológica: plant root (Rheum palmatum)
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• técnica(s): HPLC: suitable
• cor: yellow to brown
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
• chave InChI: YDQWDHRMZQUTBA-UHFFFAOYSA-N

Descrição

Descrição geral

Aloe-emodin is a hydroxyanthraquinone found naturally in aloe plants.[1][2]

Aplicação

Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).[3]

Ações bioquímicas/fisiológicas

Aloe-emodin exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects.[2]

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P301 + P312 + P330
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves