H8791
Transforming Growth Factor-β3 human
TGF-β3, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sinônimo(s):
TGF-β3
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in HEK 293 cells
Ensaio
≥95% (SDS-PAGE)
forma
lyophilized powder
potência
≤1.0 ng/mL EC50
qualidade
endotoxin tested
peso molecular
dimer 25 kDa (non-glycosylated)
embalagem
pkg of 5 μg
fabricante/nome comercial
HumanZyme
condição de armazenamento
avoid repeated freeze/thaw cycles
técnica(s)
cell culture | mammalian: suitable
Impurezas
≤1 EU/μg
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TGFB3(7043)
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Descrição geral
TGF-β3 (transforming growth factor-β3) belongs to the TGF β superfamily. The TGFβ3 gene is mapped to human chromosome 14q24.3
Ações bioquímicas/fisiológicas
TGF-β3 (transforming growth factor-β3) regulates lymphocyte proliferation, apoptosis, hematopoiesis and embryogenesis to maintain immune homeostasis. TGF-β plays an important role in cell growth, differentiation, and survival. TGF-β3 specifically promotes chondrogenic differentiation.TGF-β3 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells. TGF-2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils. TGF-β3 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. TGF-β isoforms is known to participate in wound healing and tissue fibrosis. TGF-β3 is crucial for tissue restoration and scarless tissue repair. Mutation in the TGFβ3 gene is associated with development of non-syndromic cleft palate only (NS CPO), a rare congenital disease.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.
forma física
Lyophilized from a 0.2 μm filtered solution of 50 mM NaOAc pH 4.5
Nota de preparo
HumanKine TGF-β3 is expressed in human HEK 293 cells as a mature, disulfide linked, non- glycosylated homodimer with a predicted molecular mass of 25 kDa.
This product is lyophilized from a solution of 50mM NaOAc, pH 3.7.
This product is lyophilized from a solution of 50mM NaOAc, pH 3.7.
Nota de análise
The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Informações legais
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
produto relacionado
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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