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H6166

Sigma-Aldrich

Interferon α 2B human

HumanKine®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Sinônimo(s):

IFN α 2B, IFN Alfa 2b, INF α 2B, INF Alfa 2b, Interferon Alfa 2b

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10 μG
R$ 2.010,00
5 X 10 μG
R$ 6.521,00

R$ 2.010,00

Previsão de entrega em29 de maio de 2025

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10 μG
R$ 2.010,00
5 X 10 μG
R$ 6.521,00

About This Item

Número MDL:
MFCD01773210
Código UNSPSC:
12352202
NACRES:
NA.77

R$ 2.010,00

Previsão de entrega em29 de maio de 2025

Solicite uma grande encomenda

Nome do produto

Interferon α 2B human, IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

fonte biológica

human

Nível de qualidade

100

recombinante

expressed in HEK 293 cells

Ensaio

≥95% (SDS-PAGE)

Formulário

lyophilized powder

potência

≤0.12 ng/mL EC50

qualidade

endotoxin tested

peso molecular

dimer 16 kDa (glycosylated)

embalagem

poly bottle of 10 μg (in poly bottle)

fabricante/nome comercial

HumanZyme

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤1EU/mg

nº de adesão UniProt

P01563

temperatura de armazenamento

−20°C

Informações sobre genes

human ... IFNA2(3440)

Categorias relacionadas

Descrição geral

The interferon α 2 (IFN-α2) exists in three forms 2a, 2b and 2c. It consists of 165 amino acids and five α helices. IFN-α2B is found structurally stable at pH 7. The recombinant IFN-α is nonglycosylated compared to the natural human IFN-α.[1]

Ações bioquímicas/fisiológicas

Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.

forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de preparo

HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Nota de análise

The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).

Informações legais

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCV0319
MKCT6990
MKCT2111
MKCS4606
MKCR5771

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

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Yining Wang et al.
Scientific reports, 11(1), 23465-23465 (2021-12-08)
Human coronavirus NL63 (HCoV-NL63) mainly affects young children and immunocompromised patients, causing morbidity and mortality in a subset of patients. Since no specific treatment is available, this study aims to explore the anti-SARS-CoV-2 agents including favipiravir and remdesivir for treating
Formulation and stability of cytokine therapeutics
Lipiainen T, et al.
Journal of Pharmaceutical Sciences, 104(2), 307-326 (2015)
Yang Li et al.
Antiviral research, 176, 104743-104743 (2020-02-15)
Enteric viruses including hepatitis E virus (HEV), human norovirus (HuNV), and rotavirus are causing global health issues. The host interferon (IFN) response constitutes the first-line defense against viral infections. Melanoma Differentiation-Associated protein 5 (MDA5) is an important cytoplasmic receptor sensing
Pengfei Li et al.
Science advances, 8(3), eabj5908-eabj5908 (2022-01-20)
Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. Here, we demonstrate that three-dimensional cultured organoids from fetal and
Yingxian Yin et al.
Journal of medical virology, 91(8), 1440-1447 (2019-03-23)
Plaque assay plays an irreplaceable role in a variety of virological studies, including determining titers of viruses. Our previous study showed that a simple and highly repeatable plaque assay could be used for enterovirus 71 (EV-A71). Now, we show that
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Questions

  1. What is the concentration of the product? How much PBS is needed to reconstitute it?

    1 answer

    1. This product is a lyophilized powder. Each vial contains 10 µg of interferon-α 2B. This product may be reconstituted in water or PBS.

      Please see the links below to review the product datasheet and a sample Certificate of Analysis.
      H6166 Datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/427/523/h6166pis.pdf

      H6166 Sample Certificate of Analysis:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H6166-10UG-PWMKCV0319.pdf

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