I4276
Interferon-αA human
≥95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli
Sinônimo(s):
IFN-αA, Interferon-α2A
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
≥95%
forma
buffered aqueous solution
peso molecular
19 kDa
embalagem
pkg of 20 μg
concentração
≥0.2 mg/mL
técnica(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
cor
colorless
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... IFNA2(3440)
Aplicação
Interferon-αA human has been used to:
- study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
- study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
- compare the effect of Monascus pigment derivatives on hepatitis C virus replication
Ações bioquímicas/fisiológicas
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
forma física
Supplied as a solution in 5 mM sodium acetate, pH 4.0.
Nota de análise
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Jelke J Fros et al.
Journal of virology, 84(20), 10877-10887 (2010-08-06)
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon
S-J Kim et al.
Journal of viral hepatitis, 16(10), 697-704 (2009-02-27)
Hepatitis C virus (HCV) infection is a serious threat to human health worldwide. In spite of the continued search for specific and effective anti-HCV therapies, the rapid emergence of drug-resistance variants has been hampering the development of anti-HCV drugs designed
Ji-Min Sun et al.
The Journal of antimicrobial chemotherapy, 67(1), 49-58 (2011-11-15)
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of Monascus pigment derivatives, which were derived from a microbial secondary metabolite synthesized
Shuai Shao et al.
JCI insight, 6(20) (2021-09-08)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the molecular signatures these skin disorders share are unknown. Using
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed
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