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Documentos Principais

G019

Sigma-Aldrich

Muscimol hydrobromide

≥98% (HPLC), solid

Sinônimo(s):

5-Aminomethyl-3-hydroxyisoxazole hydrobromide

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5 MG
R$ 1.569,00
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R$ 2.063,00
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R$ 3.915,00
100 MG
R$ 13.752,00

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5 MG
R$ 1.569,00
10 MG
R$ 2.063,00
25 MG
R$ 3.915,00
100 MG
R$ 13.752,00

About This Item

Fórmula empírica (Notação de Hill):
C4H6N2O2 · HBr
Número CAS:
18174-72-6
Peso molecular:
195.01
Número MDL:
MFCD00055184
Código UNSPSC:
12352200
ID de substância PubChem:
24278168
NACRES:
NA.77

R$ 1.569,00

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Ensaio

≥98% (HPLC)

Formulário

solid

cor

off-white to tan

solubilidade

H2O: >10 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Br[H].NCc1cc(O)no1

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

chave InChI

OPZOJWHOZRKYQX-UHFFFAOYSA-N

Informações sobre genes

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Ações bioquímicas/fisiológicas

Muscimol hydrobromide is a GABAA receptor agonist.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000180414
074M4744V
044M4747V
042M4617V

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Sigma-Aldrich

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Daniel H O'Connor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)
Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over
Max F K Happel et al.
PloS one, 12(1), e0169461-e0169461 (2017-01-04)
Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus
Elina A K Jacobs et al.
Current biology : CB, 30(24), 4944-4955 (2020-10-24)
In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant
Andrew Miri et al.
Neuron, 95(3), 683-696 (2017-07-25)
Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor
Suriya Subramanian et al.
Brain structure & function, 223(6), 2907-2924 (2018-04-28)
The lateral preoptic area (LPO) and ventral pallidum (VP) are structurally and functionally distinct territories in the subcommissural basal forebrain. It was recently shown that unilateral infusion of the GABAA receptor antagonist, bicuculline, into the LPO strongly invigorates exploratory locomotion
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