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D5412

Sigma-Aldrich

2′-Deoxyuridine

≥98.5%

Sinônimo(s):

1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside

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About This Item

Fórmula empírica (Notação de Hill):
C9H12N2O5
Número CAS:
951-78-0
Peso molecular:
228.20
Beilstein:
24433
Número CE:
213-455-7
Número MDL:
MFCD00006527
Código UNSPSC:
41106305
ID de substância PubChem:
24893831
NACRES:
NA.51

fonte biológica

synthetic (organic)

Ensaio

≥98.5%

forma

powder

Impurezas

Thymidine, free

solubilidade

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

cadeia de caracteres SMILES

OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

chave InChI

MXHRCPNRJAMMIM-SHYZEUOFSA-N

Informações sobre genes

mouse ... Slc29a1(63959)

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Categorias relacionadas

Aplicação

2′-Deoxyuridine has been used as a:
  • precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays
  • nucleoside supplement for cell cycle synchronization and DNA replication inhibition
  • mitotic inhibitor in culture media to minimize the proliferation of glial cells

Ações bioquímicas/fisiológicas

2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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2′-Deoxyadenosine monohydrate ≥99%

Sigma-Aldrich

D7400

2′-Deoxyadenosine monohydrate

Timidina ≥99%

Sigma-Aldrich

T9250

Timidina

3-Ureidopropionic acid ≥98.0% (T)

Sigma-Aldrich

94295

3-Ureidopropionic acid

5-Ethynyl-2′-deoxyuridine 95%

Sigma-Aldrich

900584

5-Ethynyl-2′-deoxyuridine

Uridine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

U3003

Uridine

Uridine ≥99%

Sigma-Aldrich

U3750

Uridine

α-Thymidine

Sigma-Aldrich

T3763

α-Thymidine

Yang Yang et al.
Cancer letters, 453, 170-183 (2019-04-08)
Overexpression of NQO1 is associated with poor prognosis in human cancers including lung, stomach, colon, cervical, and pancreatic cancers. However, the molecular mechanisms underlying the protumorigenic capacities of NQO1 have not been fully elucidated. Here, we investigated this question and
Quan-Liang Jian et al.
PeerJ, 6, e5739-e5739 (2018-10-09)
Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish
Kaori Nomura-Komoike et al.
Scientific reports, 10(1), 1488-1488 (2020-02-01)
Müller glia, the principal glial cell type in the retina, have the potential to reenter the cell cycle after retinal injury. In mammals, proliferation of Müller glia is followed by gliosis, but not regeneration of neurons. Retinal injury is also
Hongxiu Ning et al.
Cytotherapy, 15(1), 57-63 (2012-12-25)
Thymidine analog 5-ethynyl-2-deoxyuridine (EdU) has recently been used for tracking mesenchymal stem cells (MSCs). In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs. EdU labeling was performed
Yingqiao Wang et al.
ACS nano, 15(9), 14662-14671 (2021-08-26)
Understanding cellular electrical communications in both health and disease necessitates precise subcellular electrophysiological modulation. Nanomaterial-assisted photothermal stimulation was demonstrated to modulate cellular activity with high spatiotemporal resolution. Ideal candidates for such an application are expected to have high absorbance at
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