C8180
Cholera Toxin A Subunit from Vibrio cholerae
lyophilized powder
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About This Item
Preço e disponibilidade não estão disponíveis no momento.
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Formulário
lyophilized powder
Nível de qualidade
composição
Protein, ~5% Lowry
disponibilidade
not available in Japan
Impurezas
≤0.5% Cholera toxin B subunit (SDS-PAGE)
temperatura de armazenamento
2-8°C
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Descrição geral
Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.[1]
Aplicação
Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.[2]
Ações bioquímicas/fisiológicas
Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase
forma física
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA
Reconstituição
When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Inhalation - Aquatic Chronic 3
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Actions of cholera toxin and the prevention and treatment of cholera
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Cholera toxin: a paradigm of a multifunctional protein
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The Indian Journal of Medical Research, 133(2), 179-179 (2011)
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