C5857

CA-074 methyl ester

≥99% (TLC)

• Sinônimo(s): (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
• Fórmula empírica (Notação de Hill): C₁₉H₃₁N₃O₆
• Número CAS: 147859-80-1
• Peso molecular: 397.47
• Número MDL: MFCD03452890
• Código UNSPSC: 12352108
• ID de substância PubChem: 329775104
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 100
• Ensaio: ≥99% (TLC)
• Formulário: solid
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
• InChI: 1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
• chave InChI: XGWSRLSPWIEMLQ-RQLZCWDZSA-N

Descrição

Aplicação

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes,[1] HeLa cells[2] and human pancreatic cancer PANC-1 cells.[3]

Ações bioquímicas/fisiológicas

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type.[4] and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.[5]

Características e benefícios

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Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)