C3138
Cathepsin D from bovine spleen
lyophilized powder, ≥2.0 units/mg protein
Sinônimo(s):
CTSD
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5 UNITS
R$ 2.045,00
10 UNITS
R$ 3.586,00
20 UNITS
R$ 5.675,00
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5 UNITS
R$ 2.045,00
10 UNITS
R$ 3.586,00
20 UNITS
R$ 5.675,00
About This Item
Número CAS:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.32
Produtos recomendados
fonte biológica
bovine spleen
Ensaio
10—70% protein (biuret)
Formulário
lyophilized powder
atividade específica
≥2.0 units/mg protein
peso molecular
~45 kDa
fabricante/nome comercial
Sigma-Aldrich
técnica(s)
activity assay: suitable
cor
dark brown
adequação
suitable for molecular biology
nº de adesão UniProt
aplicação(ões)
life science and biopharma
temperatura de armazenamento
−20°C
Informações sobre genes
cow ... CTSD(282883)
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Descrição geral
Aplicação
Cathepsin D from bovine spleen has been used:
- in in vitro dose-dependent fluorometric activity assays.[3]
- in in vitro myelin oligodendrocyte glycoprotein (MOG) digestion to study the uptake of malondialdehyde (MDA)-modified MOG and its implications in central nervous system autoimmunity.[4]
- for enzymatic digestion of the proteoglycan moiety of the articular cartilage in order to determine its dynamic elastic modulus at two different levels of tissue organization.[5]
- in cathepsin D activity assay.[6]
Ações bioquímicas/fisiológicas
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts.
Definição da unidade
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
forma física
Lyophilized powder containing citrate buffer salts
Inibidor
produto relacionado
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Martin Stolz et al.
Biophysical journal, 86(5), 3269-3283 (2004-04-28)
Cartilage stiffness was measured ex vivo at the micrometer and nanometer scales to explore structure-mechanical property relationships at smaller scales than has been done previously. A method was developed to measure the dynamic elastic modulus, |E(*)|, in compression by indentation-type
Olja Mijanovic et al.
Pharmaceutics, 13(6) (2021-07-03)
Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute
Cathepsin D--many functions of one aspartic protease
Benes P, et al.
Critical Reviews in Oncology/Hematology, 68(1), 12-28 (2008)
Marie Maynadier et al.
Journal of controlled release : official journal of the Controlled Release Society, 171(2), 251-257 (2013-08-01)
Implication of the intracellular proteolytic activity of Cathepsin D (CathD), a lysosomal aspartyl-protease overexpressed in numerous solid tumors, has been evidenced on tumor growth. Its intracellular inhibition by potent inhibitors such as pepstatin constitutes a relevant but challenging molecular target.
Daming Chen et al.
Journal of virology, 88(2), 1025-1038 (2013-11-08)
Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Although predominantly lytically expressed, vIL-6 is also produced at
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