L5163

Latrunculin A

from sea sponge, ≥85% (HPLC), waxy solid

• Sinônimo(s): LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
• Fórmula empírica (Notação de Hill): C₂₂H₃₁NO₅S
• Número CAS: 76343-93-6
• Peso molecular: 421.55
• Código UNSPSC: 12352200
• ID de substância PubChem: 329817620
• NACRES: NA.77

Propriedades

• fonte biológica: sea sponge
• Nível de qualidade: 200
• Ensaio: ≥85% (HPLC)
• Formulário: waxy solid
• peso molecular: 421.6
• solubilidade: DMSO: soluble; ethanol: soluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1
• InChI: 1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
• chave InChI: DDVBPZROPPMBLW-IZGXTMSKSA-N

Descrição

Descrição geral

Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin.[1] It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.[2]

Aplicação

Latrunculin A has been used as medium supplementation for A549 cells to determine the internalization mechanism of CAV9 in A549 human lung carcinoma cells.[3]

Ações bioquímicas/fisiológicas

Latrunculin A inhibits actin polymerization by a different mechanism than cytochalasins. Latrunculin A disrupts microfilament-mediated processes.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)