The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
D7693
Dynasore hydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Sinônimo(s):
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate
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5 MG
R$ 1.042,00
25 MG
R$ 4.131,00
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5 MG
R$ 1.042,00
25 MG
R$ 4.131,00
About This Item
Fórmula empírica (Notação de Hill):
C18H14N2O4 · xH2O
Número CAS:
Peso molecular:
322.31 (anhydrous basis)
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
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Nome do produto
Dynasore hydrate,
Formulário
powder
Nível de qualidade
condição de armazenamento
protect from light
cor
off-white
solubilidade
DMSO: ≥10 mg/mL
H2O: insoluble
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
chave InChI
FKWZHQSDBMSHTN-ZIOFAICLSA-N
Descrição geral
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Aplicação
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)[3]
- in confocal microscopy[4]
- in wound healing/scratch and tube-formation assay[5]
- to analyse its effects on Coxsackievirus A9 (CAV9) infection[6]
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis[7]
- in live imaging of cells[8]
Ações bioquímicas/fisiológicas
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Características e benefícios
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Aquatic Acute 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves
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G J Hofmeyr et al.
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Artigos
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
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