Quantitative purity testing is not performed on this product. The minimum activity is 11,500 units per milligram. The maximum allowable related substances is 5.5%. These values vary from lot to lot and are reported in the product Certificate of Analysis. The amount of powder in each vial may be determined by dividing the number of units in a given package size by the lot specific activity results. For example, 10000000 units / 11500 IU per milligram = 869.6 mg per vial. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/c1511#product-documentation
C1511
Metanossulfonato sódico de colistina
~11,500 U/mg
Sinônimo(s):
Colimicina sódica, Polimixina E sódica, Ácido metanossulfônico derivado de polimixina E
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10000000 UNITS
R$ 1.986,00
100000000 UNITS
R$ 12.371,00
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10000000 UNITS
R$ 1.986,00
100000000 UNITS
R$ 12.371,00
About This Item
Fórmula empírica (Notação de Hill):
C58H115N16Na5O28S5
Número CAS:
Peso molecular:
1759.90
Número CE:
Número MDL:
Código UNSPSC:
51102829
ID de substância PubChem:
NACRES:
NA.85
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Formulário
powder
atividade específica
~11,500 U/mg
solubilidade
H2O: 50 mg/mL
espectro de atividade do antibiótico
Gram-negative bacteria
Modo de ação
cell membrane | interferes
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
InChI
1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
chave InChI
WSDSONZFNWDYGZ-BKFDUBCBSA-I
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Categorias relacionadas
Descrição geral
Chemical structure: peptide
Aplicação
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
Ações bioquímicas/fisiológicas
Modo de ação: Liga-se a lipídios na membrana citoplasmática da célula de bactérias gram negativas e prejudica a integridade da parede celular.
Espectro da ação antimicrobiana: Bactérias gram negativas.
Espectro da ação antimicrobiana: Bactérias gram negativas.
Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin.[1][2] Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.[3][1]
Outras notas
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Sachin Gupta et al.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 13(2), 49-53 (2009-11-03)
One of the greatest achievements of modern medicine is the development of antibiotics against life-threatening infections, but the emergence of multidrug-resistant (MDR) gram negative bacteria has drastically narrowed down the therapeutic options against them. This limitation has led clinicians to
Matthew E Falagas et al.
Expert review of anti-infective therapy, 6(5), 593-600 (2008-10-14)
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative
Roberto Imberti et al.
Chest, 138(6), 1333-1339 (2010-06-19)
Infections caused by multidrug-resistant gram-negative bacteria have caused a resurgence of interest in colistin. To date, information about pharmacokinetics of colistin is very limited in critically ill patients, and no attempts have been made to evaluate its concentration in BAL.
M.J. Rogers et al.
Infection (Munich), 14, 79-79 (1986)
S M Garonzik et al.
Antimicrobial agents and chemotherapy, 55(7), 3284-3294 (2011-05-11)
With increasing clinical emergence of multidrug-resistant Gram-negative pathogens and the paucity of new agents to combat these infections, colistin (administered as its inactive prodrug colistin methanesulfonate [CMS]) has reemerged as a treatment option, especially for critically ill patients. There has
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How I can convert U/mg (specific activity of this product) to mg/mg? Thanks
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