B2643

Biotinamidohexanoic acid N-hydroxysuccinimide ester

≥98% (TLC), powder

• Sinônimo(s): (+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NHS ester, N-Succinimidyl N-biotinyl-6-aminocaproate, Succinimidyl 6-(biotinamido)hexanoate
• Fórmula empírica (Notação de Hill): C₂₀H₃₀N₄O₆S
• Número CAS: 72040-63-2
• Peso molecular: 454.54
• Beilstein: 3577403
• Número MDL: MFCD00065502
• Código UNSPSC: 12352203
• ID de substância PubChem: 24891665
• NACRES: NA.46

Propriedades

• Ensaio: ≥98% (TLC)
• forma: powder
• solubilidade: H₂O: ≤2 mg/mL (with sonication); DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2
• InChI: 1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1
• chave InChI: UVGHPGOONBRLCX-NJSLBKSFSA-N

Descrição

Aplicação

Biotinamidohexanoic acid N-hydroxysuccinimide ester has been used in the biotinylation of antibodies.

Ações bioquímicas/fisiológicas

Biotin is a label widely used in several biochemical applications and has a high affinity for avidin. A spacer chain is required to reduce steric hindrance while coupling biotin (a small molecule) to biopolymers (large molecules). Biotinamidohexanoic acid N-hydroxysuccinimide ester incorporates a 7-atom spacer with the N-succinimide leaving group. It can react with a primary amine in the pH range of 6.5-8.5. This biotinylation reagent incorporates an aminocaproyl spacer and thus can reduce the steric hindrance in binding avidin to some biotinylated compounds.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)