A6955
Angiogenin human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinônimo(s):
ANG
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50 μG
R$ 6.153,00
R$ 6.153,00
Previsão de entrega em22 de maio de 2025
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50 μG
R$ 6.153,00
About This Item
R$ 6.153,00
Previsão de entrega em22 de maio de 2025
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Ensaio
≥97% (SDS-PAGE)
Formulário
lyophilized powder
peso molecular
14.4 kDa
embalagem
pkg of 50 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
técnica(s)
cell culture | mammalian: suitable
Impurezas
endotoxin, tested
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... ANG(283)
Descrição geral
Angiogenin is a secreted growth factor. It is localized in the tissue fluids such as plasma, amniotic fluid, cerebrospinal fluid and tumor microenvironment.[1]
Aplicação
Ações bioquímicas/fisiológicas
Angiogenin plays a role in several biological functions such as tumorigenesis, innate immunity, neuroprotection. It also plays a role in reproduction, regeneration of damaged tissues and neovascularization.[1]
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.
Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Nota de análise
The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.[4]
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Human angiogenin lacks specific antimicrobial activity
Avdeeva, Svetlana V, et al.
Current Microbiology, 53(6), 477-478 (2006)
J Badet
Pathologie-biologie, 47(4), 345-351 (1999-06-18)
Angiogenin is a heparin-binding 14 kDa plasma protein with angiogenic and ribonucleolytic activity. Although its structural features have been extensively studied, an understanding of its physiological role and of how its properties are expressed continues to elude researchers. This article
Three decades of research on angiogenin: a review and perspective
Sheng J and Xu Z
Acta biochimica et biophysica Sinica, 48(5), 399-410 (2016)
Evaluation of angiogenesis in diabetic lower limb wound healing using a natural medicine: A quantitative approach
Barui A, et al.
Wounds : a compendium of clinical research and practice, 6, 26-33 (2014)
D J Strydom
Cellular and molecular life sciences : CMLS, 54(8), 811-824 (1998-10-07)
The angiogenic and other biological functions of the angiogenins, members of the pancreatic RNase superfamily of proteins, are reviewed in the context of their primary and tertiary structures. The ribonucleolytic activity and interactions with the placental ribonuclease inhibitor have seen
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