S1129

Succinyl coenzyme A sodium salt

≥85%

• Sinônimo(s): Succinyl CoA sodium salt
• Fórmula empírica (Notação de Hill): C₂₅H₄₀N₇O₁₉P₃S
• Número CAS: 108347-97-3
• Peso molecular: 867.61
• Código UNSPSC: 41106305
• ID de substância PubChem: 24899460
• NACRES: NA.51

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥85%
• Formulário: powder
• solubilidade: water: 50 mg/mL, clear, colorless
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O
• InChI: 1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-2/t13-,18-,19-,20?,24-/m1/s1
• chave InChI: VNOYUJKHFWYWIR-FZEDXVDRSA-L

Descrição

Aplicação

Succinyl coenzyme A sodium salt has been used:

• for the nonenzymatic succinylation of lysine in vitro[1],
• as a substrate for adipic acid biosynthesis in recombinant E. coli [2]
• in isocitrate dehydrogenase (ICDH) treatment for the succinylation of proteins[3]
• as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)

Ações bioquímicas/fisiológicas

Succinyl CoA is an intermediate in the citric acid cycle.[4] It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids.[5] Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves