A3134

3-Aminopropionitrile fumarate salt

metabolite

• Sinônimo(s): β-Alaninenitrile
• Fórmula linear: NH₂CH₂CH₂CN · ½ (HO₂CCH=CHCO₂H)
• Número CAS: 2079-89-2
• Peso molecular: 128.13
• Beilstein: 3573532
• Número CE: 218-208-7
• Número MDL: MFCD00013142
• Código UNSPSC: 12352202
• ID de substância PubChem: 24278224
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• Formulário: powder
• pf: 177 °C (dec.) (lit.)
• solubilidade: water: 50 mg/mL, clear, colorless to faintly yellow
• cadeia de caracteres SMILES: NCCC#N.NCCC#N.OC(=O)\C=C\C(O)=O
• InChI: 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;;
• chave InChI: NYMXYZMHOZAPHQ-SEPHDYHBSA-N

Descrição

Aplicação

3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:

• to inhibit collagen cross-linking during microtissue formation and culture[1]
• in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay[2]
• in lysyl oxidase (LOX) activity assay[3]
• to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids[4]

Ações bioquímicas/fisiológicas

3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.[1]

In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360FD
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges