87128

Tetracycline

98.0-102.0% (HPLC)

• Sinônimo(s): Tetracycline HCL, Tetracycline Monohydrochloride
• Fórmula empírica (Notação de Hill): C₂₂H₂₄N₂O₈ · xH₂O
• Número CAS: 60-54-8
• Peso molecular: 444.43 (anhydrous basis)
• Beilstein: 2230417
• Número CE: 200-481-9
• Número MDL: MFCD00151232
• Código UNSPSC: 51284017
• ID de substância PubChem: 57653229
• NACRES: NA.85

Propriedades

• fonte biológica: synthetic
• Ensaio: 98.0-102.0% (HPLC)
• forma: powder or crystals
• cor: faint yellow to dark yellow
• pf: 172-174 °C (dec.)
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• chave InChI: OFVLGDICTFRJMM-WESIUVDSSA-N
• Informações sobre genes: human ... CYP1A2(1544) , TERT(7015)

Descrição

Descrição geral

Chemical structure: tetracycline

Ações bioquímicas/fisiológicas

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Embalagem

25g, 100g

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H361fd,H411
• Declarações de precaução: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves