59983

Josamycin

≥90% (HPLC)

• Sinônimo(s): Leucomycin A3
• Fórmula empírica (Notação de Hill): C₄₂H₆₉NO₁₅
• Número CAS: 16846-24-5
• Peso molecular: 827.99
• Número CE: 240-871-6
• Número MDL: MFCD00211043
• Código UNSPSC: 51102829
• ID de substância PubChem: 57651709
• NACRES: NA.85

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• forma: powder
• cor: white to slightly yellow
• espectro de atividade do antibiótico: Gram-positive bacteria
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
• InChI: 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1
• chave InChI: XJSFLOJWULLJQS-NGVXBBESSA-N

Descrição

Descrição geral

Chemical structure: macrolide

Aplicação

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Ações bioquímicas/fisiológicas

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)