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Documentos

N9890

Supelco

Norfloxacin

analytical standard, ≥98% (TLC)

Sinônimo(s):

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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About This Item

Fórmula empírica (Notação de Hill):
C16H18FN3O3
Número CAS:
70458-96-7
Peso molecular:
319.33
Número CE:
274-614-4
Número MDL:
MFCD00079532
Código UNSPSC:
41116107
ID de substância PubChem:
329818696
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

200

Agency

EPA 1694

Ensaio

≥98% (TLC)

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

clinical testing

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

chave InChI

OGJPXUAPXNRGGI-UHFFFAOYSA-N

Informações sobre genes

human ... CYP1A2(1544)
rat ... Gabra1(29705)

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Categorias relacionadas

Descrição geral

Chemical structure: fluoroquinolone
Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria.

Aplicação

Norfloxacin may be used as a standard in the determination of norfloxacin in human serum samples using fluorometric spectrophotometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
0000227061
0000249280
0000249279
0000227061
0000249280

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Norfloxacin-d5 VETRANAL®, analytical standard

Supelco

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Oxolinic acid quinolone antibiotic

Sigma-Aldrich

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Oxolinic acid

Lomefloxacin hydrochloride

Sigma-Aldrich

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Y0001423

Difloxacin hydrochloride

Pefloxacin mesylate dihydrate

Sigma-Aldrich

P0106

Pefloxacin mesylate dihydrate

L M Cavaco et al.
Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)
Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not
Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium
Djurdjevic.TP, et al.
Analytica Chimica Acta, 300, 253-259 (1995)
Deepika Sharma et al.
European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
Anita Reinhardt et al.
Antimicrobial agents and chemotherapy, 51(4), 1341-1350 (2007-01-31)
Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of
Kristine H Wammer et al.
Water research, 47(1), 439-448 (2012-11-13)
Fluoroquinolone (FQ) antibacterial compounds are frequently detected in the aquatic environment, and photodegradation is expected to play an important role in FQ fate in some sunlit surface waters. This study investigated the direct aquatic photochemistry of three FQs: norfloxacin, ofloxacin
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Artigos

Inhibition of Nucleic Acid Synthesis by Antibiotics

Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II (DNA gyrase), an enzyme involved in DNA replication.

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