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Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Sinônimo(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

Fórmula linear:
CH3O(CH2CH2O)nCOCH2CH2COOH
Número CAS:
31961-02-1
Número MDL:
MFCD00284260
Código UNSPSC:
51171641
NACRES:
NA.26

forma

powder

peso molecular

Mr ~2100

pf

50-53 °C

Ω-final

carboxylic acid

α-final

methoxy

temperatura de armazenamento

−20°C

Aplicação

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Ações bioquímicas/fisiológicas

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Sigma-Aldrich

JKA3016

mPEG10K-Succinimidyl Carboxymethyl Ester

4-Azidobenzoic acid solution ~0.2 M in tert-butyl methyl ether, ≥95.0% (HPLC)

Sigma-Aldrich

778877

4-Azidobenzoic acid solution

Poly(ethylene glycol) methyl ether average Mn ~2,000

Sigma-Aldrich

202509

Poly(ethylene glycol) methyl ether

Poli(etilenoglicol) 2000, for synthesis

Sigma-Aldrich

8.21037

Poli(etilenoglicol)

DCC 99%

Sigma-Aldrich

D80002

DCC

Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [(3)H]-hypoxanthine in the nucleic acid of parasites. Stearylamine in liposomes significantly inhibits the growth of
Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Peter M Fischer et al.
Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid-phase chemistries and combines the inherent advantages of both approaches. The technical simplicity and scalability of the liquid-phase peptide synthesis method renders
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
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