Methoxypolyethylene glycol 1,000 propionic acid is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.
European journal of medicinal chemistry, 46(8), 3388-3397 (2011-05-24)
Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibiotics-macrolones-derived from azithromycin, comprising oxygen atom(s) in the linker and either free or esterified quinolone 3-carboxylic group, are reported. Selected compounds showed excellent antibacterial potency towards key erythromycin
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has recently proven to be a powerful synthetic tool in various fields of chemistry, including protein-polymer conjugation. In this article, we describe a fluorogenic CuAAC, which allows for efficient monitoring of protein-polymer conjugation. We show
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