BP1083

Isoniazid

British Pharmacopoeia (BP) Reference Standard

• Sinônimo(s): 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Fórmula empírica (Notação de Hill): C₆H₇N₃O
• Número CAS: 54-85-3
• Peso molecular: 137.14
• Beilstein: 119374
• Número MDL: MFCD00006426
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: isoniazid
• Formulário: powder
• prazo de validade: limited shelf life, expiry date on the label
• fabricante/nome comercial: BP
• pf: 171-173 °C (lit.)
• aplicação(ões): pharmaceutical; pharmaceutical small molecule
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• chave InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Isoniazid BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Isoniazid Oral Solution

Ações bioquímicas/fisiológicas

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Embalagem

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H315
• Declarações de precaução: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classificações de perigo: Acute Tox. 4 Oral - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3