52619

Hexamethyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Sinônimo(s): HMDS
• Fórmula linear: (CH₃)₃SiNHSi(CH₃)₃
• Número CAS: 999-97-3
• Peso molecular: 161.39
• Beilstein: 635752
• Número CE: 213-668-5
• Número MDL: MFCD00008259
• Código UNSPSC: 12000000
• ID de substância PubChem: 329757861
• NACRES: NA.22

Propriedades

• grau: for GC derivatization
• Nível de qualidade: 100
• Ensaio: ≥99.0% (GC)
• Formulário: liquid
• qualidade: LiChropur^™
• adequação da reação: reagent type: derivatization reagent; reaction type: Silylations
• técnica(s): gas chromatography (GC): suitable
• índice de refração: n20/D 1.407 (lit.); n20/D 1.408
• p.e.: 125 °C (lit.)
• cadeia de caracteres SMILES: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
• chave InChI: FFUAGWLWBBFQJT-UHFFFAOYSA-N

Descrição

Descrição geral

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent,[1][2] which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.[2]

Aplicação

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites,[3] phenol, hydroquinone and catechol[4] in urine samples, mixtures of free fatty acids and metal soaps in paint samples[5] using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Características e benefícios

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Outras notas

Important silylating agent[6][7]

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Informações legais

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS06
• Palavra indicadora: Danger
• Frases de perigo: H225,H302 + H332,H311,H412
• Declarações de precaução: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 52.5 °F - closed cup
• Ponto de fulgor (°C): 11.4 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter