8.17073

Fumaric acid

EMPROVE^® ESSENTIAL, NF, JPE

• Sinônimo(s): Fumaric acid, trans-1,2-Ethylentricarboxylic acid
• Fórmula empírica (Notação de Hill): C₄H₄O₄
• Número CAS: 110-17-8
• Peso molecular: 116.07
• Número MDL: MFCD00002700
• Código UNSPSC: 12352106
• Número do índice EC: 203-743-0

Propriedades

• Agency: JPE; NF
• Nível de qualidade: 500
• pressão de vapor: <0.001 hPa ( 20 °C)
• linha de produto: EMPROVE^® ESSENTIAL
• forma: solid
• temperatura de autoignição: 375 °C
• potência: 9300 mg/kg LD₅₀, oral (Rat); 20000 mg/kg LD₅₀, skin (Rabbit)
• técnica(s): API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 2.1 (20 °C, 4.9 g/L in H₂O)
• pb: 290 °C/1013 hPa (sublimed)
• pf: 287 °C
• temperatura de transição: flash point 273 °C
• solubilidade: 4.9 g/L
• densidade: 1.64 g/cm³ at 20 °C
• aplicação(ões): liquid formulation; pharmaceutical; solid formulation
• temperatura de armazenamento: 15-25°C
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
• chave InChI: VZCYOOQTPOCHFL-OWOJBTEDSA-N

Descrição

Descrição geral

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Fumaric acid is a commonly used ingredient in both food and pharmaceutical applications. In pharmaceutical applications, fumaric acid has been used primarily as a pH modifier.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319
• Declarações de precaução: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 523.4 °F
• Ponto de fulgor (°C): 273 °C