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572201

Millipore

Streptozotocin

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Sinônimo(s):

Streptozotocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

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About This Item

Fórmula empírica (Notação de Hill):
C8H15N3O7
Número CAS:
Peso molecular:
265.22
Número MDL:
Código UNSPSC:
12352103
Preço e disponibilidade não estão disponíveis no momento.

Nível de qualidade

Ensaio

≥95% (HPLC)

Formulário

crystalline solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

cor

off-white to pale yellow

solubilidade

water: soluble

traços de cátion

heavy metals: ≤5 ppm

Condições de expedição

ambient

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

N(N=O)(C)C(=O)N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

chave InChI

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

Descrição geral

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells. A diabetogenic agent.
An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstituição

Unstable in solution; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-20°C).

Outras notas

Kroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994. FASEB J.8, 529.
Rasschaert, J., et al. 1992. Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E. 1981. Cancer Res.41, 2786.
Yamamoto, H., et al. 1981. Nature294, 284.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

FlameHealth hazard

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Carc. 2 - Flam. Sol. 1 - Muta. 2

Código de classe de armazenamento

4.1B - Flammable solid hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high‑fat diet and streptozotocin‑induced type 2 diabetes mellitus (T2DM) mouse model.
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Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated the autophagy‑associated regulatory mechanisms of long non‑coding RNAs in cardiac pathological changes in diabetes mellitus (DM). Streptozotocin (STZ)‑induced

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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