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557502

Sigma-Aldrich

Ro-20-1724

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

Sinônimo(s):

Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

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About This Item

Fórmula empírica (Notação de Hill):
C15H22N2O3
Número CAS:
29925-17-5
Peso molecular:
278.35
Número MDL:
MFCD00077397
Código UNSPSC:
12352200
NACRES:
NA.77

product name

Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).

Nível de qualidade

100

Ensaio

≥98% (TLC)

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

cor

white

solubilidade

DMSO: 20%
ethanol: 4%

Condições de expedição

ambient

temperatura de armazenamento

10-30°C

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

chave InChI

PDMUULPVBYQBBK-UHFFFAOYSA-N

Descrição geral

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Ações bioquímicas/fisiológicas

Cell permeable: yes
Primary Target
PDE IV
Product does not compete with ATP.
Reversible: no
Target IC50: 2 µM against PDE IV

Advertência

Toxicity: Irritant (B)

Outras notas

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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