86872

Tetrabutylammonium fluoride trihydrate

≥97.0% (NT)

• Sinônimo(s): TBAF
• Fórmula linear: [CH₃(CH₂)₃]₄NF · 3H₂O
• Número CAS: 87749-50-6
• Peso molecular: 315.51
• Beilstein: 3761900
• Número CE: 207-057-2
• Número MDL: MFCD00149981
• Código UNSPSC: 12352107
• ID de substância PubChem: 57653206
• NACRES: NA.22
• Formulário: crystals
• Ensaio: ≥97.0% (NT)

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥97.0% (NT)
• Formulário: crystals
• pf: 62-63 °C (lit.)
• grupo funcional: amine
• cadeia de caracteres SMILES: O.O.O.[F-].CCCC[N+](CCCC)(CCCC)CCCC
• InChI: 1S/C16H36N.FH.3H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;;;/h5-16H2,1-4H3;1H;3*1H2/q+1;;;;/p-1
• chave InChI: VEPTXBCIDSFGBF-UHFFFAOYSA-M

Descrição

Descrição geral

Tetrabutylammonium fluoride trihydrate is a mild base used in reactions like aldol-type condensation reactions, Michael-type reactions, ring-opening reactions. Its is also used as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.

Aplicação

Reactant for:
Preparation of deprotecting agents in preparation of cellulose derivatives
Synthesis of lipophilic peptides for DNA transfections in vivo
Dehydrobromination reactions

Tetrabutylammonium fluoride trihydrate can be used as a base:

• For the dehydrobromination of vinyl bromides to terminal acetylenes.
• In the conversion of 1,1-dibromo-1-alkenes to terminal alkynes via Corey–Fuchs reaction.
• In Hiyama cross-coupling reaction of aryl and heteroaryl chlorides with aryltrialkoxysilanes in the presence of a palladium catalyst.

It can be used to catalyze ethynylation of quinolines and isoquinolines using calcium carbide in aqueous N,N-dimethylacetamide.

Outras notas

Reagent for the cleavage of silyl ethers and other silyl protecting groups; Catalyst for various reactions with silicon compounds; Use as a base in organic synthesis; Instability of anhydrous TBAF

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H319,H361fd,H412
• Declarações de precaução: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges