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PHL89593

Camptothecin

phyproof® Reference Substance

Synonym(e):

(S)-(+)-Camptothecin

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About This Item

Empirische Formel (Hill-System):
C20H16N2O4
CAS-Nummer:
7689-03-4
Molekulargewicht:
348.35
Beilstein:
631069
MDL-Nummer:
MFCD00081076
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

primary reference standard

Produktlinie

phyproof® Reference Substance

Assay

≥90.0% (HPLC)

Form

powder

Hersteller/Markenname

PhytoLab

mp (Schmelzpunkt)

260 °C (dec.) (lit.)

Lagertemp.

2-8°C

SMILES String

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O

InChI

1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChIKey

VSJKWCGYPAHWDS-FQEVSTJZSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Anwendung




  • Co-delivery system for camptothecin and doxorubicin: Research on dendritic polymer prodrug-based unimolecular micelles demonstrated a pH-responsive co-delivery mechanism for camptothecin and doxorubicin, offering a synergistic effect in controlled drug release (Chen and Liu, 2024).


  • Investigation into camptothecin′s role in chronic myeloid leukemia: The study explored the therapeutic potential of FL118, a camptothecin derivative, against chronic myeloid leukemia resistant to BCR-ABL inhibitors, targeting RNA helicase DDX5 (Takeda et al., 2024).


Rechtliche Hinweise

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H301,H340

Gefahreneinstufungen

Acute Tox. 3 Oral - Muta. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
73551
113560738
110163746

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Die Dokumentenbibliothek aufrufen

Raju Suresh Kumar et al.
Saudi journal of biological sciences, 27(12), 3290-3300 (2020-12-12)
A small library of cage-like heterocyclic hybrids encompassing pyrroloisoquinolines, pyridinone and acenaphthene structural moieties have been synthesized and tested for their potential as anticancer agents against HCT116 and JURKAT cell lines. The results revealed that these cell lines are more
Katerina D Fagan-Solis et al.
Cell reports, 30(5), 1385-1399 (2020-02-06)
The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model
Jun Ho Ko et al.
Cell reports, 33(12), 108543-108543 (2020-12-29)
DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for HR. The

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