Stock solutions of this product may be stored at -20 °C for up to three months in aliquots. Stability data has not been collected for stock solutions at 2-8°C. This product does not need to be protected from light as it is not light-sensitive. Please see the link below to review the product datasheet for additional information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/385/900/c9911pis.pdf
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100 MG
€ 314,00
250 MG
€ 683,00
1 G
€ 1.340,00
Über diesen Artikel
Empirische Formel (Hill-System):
C20H16N2O4
CAS-Nummer:
Molekulargewicht:
348.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
631069
Assay:
≥90% (HPLC)
Form:
powder
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Unterstützung erhaltenProduktname
(S)-(+)-Camptothecin, ≥90% (HPLC), powder
assay
≥90% (HPLC)
form
powder
mp
260 °C (dec.) (lit.)
solubility
chloroform/methanol (4:1): 5 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChI key
VSJKWCGYPAHWDS-FQEVSTJZSA-N
Gene Information
human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)
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Verwandte Kategorien
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C |
| solubility chloroform/methanol (4:1): 5 mg/mL | solubility DMSO: 10 mg/mL, methanol: 40 mg/mL | solubility DMSO: 50 mg/mL | solubility DMSO: 2 mg/mL, clear (Warmed) |
| mp 260 °C (dec.) (lit.) | mp - | mp - | mp - |
Biochem/physiol Actions
(S)-(+)-Camptothecin bindet irreversibel an den DNA-Topoisomerase-I-Komplex, hemmt die Reassoziation der DNA nach der Spaltung durch Topoisomerase I und fängt das Enzym in einer kovalenten Bindung mit der DNA ein. Der Enzymkomplex wird durch das 26S-Proteasom ubiquiniert und zerstört, wodurch die zelluläre Topoisomerase I abgebaut wird. Blockiert den Zellzyklus in der S-Phase bei niedriger Dosis und induziert Apoptose in einer großen Anzahl von normalen und Tumorzelllinien durch zellzyklusabhängige und zellzyklusunabhängige Prozesse.
Features and Benefits
Diese Verbindung ist ein wichtiges Produkt für die Forschung im Bereich der Apoptose. Informationen über weitere empfohlene Apoptoseprodukte finden Sie hier. Weitere Informationen über bioaktive kleine Moleküle für andere Forschungsbereiche finden Sie unter: sigma.com/discover-bsm.
Other Notes
20S-Isomer
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 1B
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Verwandter Inhalt
Autophagy in Cancer
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C9911-100MG | 04061833531389 |
| C9911-1G | 04061826726495 |
| C9911-250MG | 04061835512393 |
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How long can (S)-(+)-camptothecin C9911 be stored at 2-8°C? Should it be protected from light? Is it light-sensitive?
1 answer-
Helpful?
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What is Product C9911, (S)-(+)-Camptothecin, soluble in?
1 answer-
This product is soluble in DMSO (10 mg/mL). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95°C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/mL) and methanol (50 mg/mL).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the solution stability of Product C9911, (S)-(+)-Camptothecin?
1 answer-
Stock solutions of camptothecin in DMSO can be stored at -20°C for up to 3 months.
Helpful?
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What is the extinction coefficient of Product C9911, (S)-(+)-Camptothecin?
1 answer-
The millimolar extinction coefficients (EmM) at various wavelengths are 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm).
Helpful?
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