T2705

Topotecan hydrochloride hydrate

≥98% (HPLC and enzymatic), powder, topoisomerase I inhibitor

• Synonym(e): 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate, NSC-609669 hydrochloride hydrate, SKF-104864A hydrochloride hydrate, hycamptamine hydrochloride hydrate
• Empirische Formel (Hill-System): C₂₃H₂₃N₃O₅ · xHCl · yH₂O
• CAS-Nummer: 123948-87-8
• Molekulargewicht: 421.45 (anhydrous free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826724
• NACRES: NA.77
• MDL number: MFCD00870670
• Assay: ≥98% (HPLC and enzymatic)
• Form: powder
• Storage condition: desiccated, protect from light

Eigenschaften

• Produktname: Topotecan hydrochloride hydrate, ≥98% (HPLC and enzymatic)
• Quality Segment: 100
• assay: ≥98% (HPLC and enzymatic)
• form: powder
• storage condition: desiccated, protect from light
• color: yellow
• solubility: DMSO: ≥20 mg/mL
• originator: GlaxoSmithKline
• storage temp.: −20°C
• SMILES string: [n]21c(cc5c([c]2=O)COC(=O)[C@]5(O)CC)c3nc4c(cc3C1)c(c(cc4)O)CN(C)C
• InChI: 1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
• InChI key: UCFGDBYHRUNTLO-QHCPKHFHSA-N
• Gene Information: human ... TOP1MT(116447)

Beschreibung

Application

Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions¹. It has also been used for in vitro apoptosis assays in PA317 cells².

Biochem/physiol Actions

Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.

Features and Benefits

This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is soluble in water, however, the concentration has not been determined. Various sources state this chemical can be solubilized in water at greater than 1 mg/mL.

Topotecan hydrochloride hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H340,H361d
• Sicherheitshinweise: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable